SrasV1, Main, Exploration, bibRecord, 002032

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

Identifieur interne : 002032 ( Main/Exploration ); précédent : 002031; suivant : 002033

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

Auteurs : Thomas Kuri [Allemagne] ; Klara K. Eriksson [Suisse] ; Akos Putics [Allemagne] ; Roland Züst [Suisse] ; Eric J. Snijder [Pays-Bas] ; Andrew D. Davidson [Royaume-Uni] ; Stuart G. Siddell [Royaume-Uni] ; Volker Thiel [Suisse] ; John Ziebuhr [Allemagne] ; Friedemann Weber [Allemagne]

Source :

The Journal of general virology [ 1465-2099 ] ; 2011.

RBID : pubmed:21525212

Descripteurs français

English descriptors

KwdEn :
- Amino Acid Sequence, Antiviral Agents (immunology), Cell Line, Coronavirus 229E, Human (chemistry), Coronavirus 229E, Human (enzymology), Coronavirus 229E, Human (genetics), Coronavirus 229E, Human (immunology), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Coronavirus Infections (virology), Humans, Interferon-alpha (genetics), Interferon-alpha (immunology), Molecular Sequence Data, Phosphoric Monoester Hydrolases (chemistry), Phosphoric Monoester Hydrolases (genetics), Phosphoric Monoester Hydrolases (immunology), Protein Structure, Tertiary, SARS Virus (chemistry), SARS Virus (drug effects), SARS Virus (enzymology), SARS Virus (genetics), Sequence Alignment, Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Viral Proteins (chemistry), Viral Proteins (genetics), Viral Proteins (immunology).
MESH :
- chemical , chemistry : Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , genetics : Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemical , immunology : Antiviral Agents, Interferon-alpha, Phosphoric Monoester Hydrolases, Viral Proteins.
- chemistry : Coronavirus 229E, Human, SARS Virus.
- drug effects : SARS Virus.
- enzymology : Coronavirus 229E, Human, SARS Virus.
- genetics : Coronavirus 229E, Human, Coronavirus Infections, SARS Virus, Severe Acute Respiratory Syndrome.
- immunology : Coronavirus 229E, Human, Coronavirus Infections, Severe Acute Respiratory Syndrome.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Amino Acid Sequence, Cell Line, Humans, Molecular Sequence Data, Protein Structure, Tertiary, Sequence Alignment.

Abstract

Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.

DOI: 10.1099/vir.0.031856-0
PubMed: 21525212

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Several plus-strand RNA viruses encode proteins containing macrodomains. These domains possess ADP-ribose-1″-phosphatase (ADRP) activity and/or bind poly(ADP-ribose), poly(A) or poly(G). The relevance of these activities in the viral life cycle has not yet been resolved. Here, we report that genetically engineered mutants of severe acute respiratory syndrome coronavirus (SARS-CoV) and human coronavirus 229E (HCoV-229E) expressing ADRP-deficient macrodomains displayed an increased sensitivity to the antiviral effect of alpha interferon compared with their wild-type counterparts. The data suggest that macrodomain-associated ADRP activities may have a role in viral escape from the innate immune responses of the host.</div>
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<name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name>
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{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:21525212
   |texte=   The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.
}}

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This area was generated with Dilib version V0.6.33.
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Serveur d'exploration SRAS

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

The ADP-ribose-1''-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses.

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